Courtot Lab Genome Informatics

Publications

Our research focuses on new methods for improving data quality, based on knowledge representation, automated curation and added-value data. We have published over 50 papers with over 11,000 citations.

All

2024

The Canadian VirusSeq Data Portal & Duotang: open resources for SARS-CoV-2 viral sequences and genomic epidemiology
EE Gill, B Jia, CL Murall, R Poujol, MZ Anwar, NS John, J Richardsson, ...
arXiv preprint arXiv:2405.04734, 2024
Toward a common standard for data and specimen provenance in life sciences
R Wittner, P Holub, C Mascia, F Frexia, H Müller, M Plass, C Allocca, ...
Learning health systems 8 (1), e10365, 2024

2023

ELIXIR biovalidator for semantic validation of life science metadata (vol 38, pg 3141, 2022)
I Liyanage, T Burdett, B Droesbeke, K Erdos, R Fernandez, A Gray, ...
BIOINFORMATICS 39 (1), 2023
Accelerating cancer omics and precision oncology in health care and research: a Lancet Oncology Commission
R Casolino, AL Johns, M Courtot, RT Lawlor, F De Lorenzo, D Horgan, ...
The lancet oncology 24 (2), 123-125, 2023
Features of a FAIR vocabulary
F Xu, N Juty, C Goble, S Jupp, H Parkinson, M Courtot
Journal of Biomedical Semantics 14 (1), 6, 2023
FAIR in action-a flexible framework to guide FAIRification
D Welter, N Juty, P Rocca-Serra, F Xu, D Henderson, W Gu, J Strubel, ...
Scientific data 10 (1), 291, 2023

2022

Features of a FAIR Vocabulary
H Parkinson, M Courtot
[no publisher info]
ELIXIR biovalidator for semantic validation of life science metadata
I Liyanage, T Burdett, B Droesbeke, K Erdos, R Fernandez, A Gray, ...
Bioinformatics 38 (11), 3141-3142, 2022
Recommendations for the formatting of Variant Call Format (VCF) files to make plant genotyping data FAIR
S Beier, A Fiebig, C Pommier, I Liyanage, M Lange, PJ Kersey, S Weise, ...
F1000Research 11, 2022
BioSamples database: FAIRer samples metadata to accelerate research data management
M Courtot, D Gupta, I Liyanage, F Xu, T Burdett
Nucleic acids research 50 (D1), D1500-D1507, 2022
The GA4GH Phenopacket schema defines a computable representation of clinical data
JOB Jacobsen, M Baudis, GS Baynam, JS Beckmann, S Beltran, ...
Nature biotechnology 40 (6), 817-820, 2022

2021

The GA4GH Phenopacket schema: A computable representation of clinical data for precision medicine
Julius O. B. Jacobsen, Michael Baudis, Gareth S. Baynam, Jacques S. Beckmann, Sergi Beltran, ..., Alex H. Wagner, Jeremy L. Warner, Claus Weiland, Melissa A. Haendel, Peter N. Robinson
Cold Spring Harbor Laboratory
BioSamples database: FAIRer samples metadata to accelerate research data management
Mélanie Courtot, Dipayan Gupta, Isuru Liyanage, Fuqi Xu, Tony Burdett
Nucleic Acids Research
The Data Use Ontology to streamline responsible access to human biomedical datasets
Jonathan Lawson, Moran N. Cabili, Giselle Kerry, Tiffany Boughtwood, Adrian Thorogood, ..., Chisato Yamasaki, Lyndon Zass, Jaime M. Guidry Auvil, Tommi H. Nyrönen, Mélanie Courtot
Cell Genomics
Towards a Common Standard for Data and Specimen Provenance in Life Sciences
P Holub, B Kisler, A Kremer, S Lin-Gibson, A Marsano, M Mattavelli, ...
Zenodo, 2021
The GA4GH Phenopacket schema: A computable representation of clinical data for precision medicine
JOB Jacobsen, M Baudis, GS Baynam, JS Beckmann, S Beltran, ...
medRxiv, 2021.11. 27.21266944, 2021
Empirical validation of an automated approach to data use oversight
MN Cabili, J Lawson, A Saltzman, G Rushton, P O’Rourke, J Wilbanks, ...
Cell Genomics 1 (2), 2021
GA4GH Passport standard for digital identity and access permissions
C Voisin, M Linden, SOM Dyke, SR Bowers, P Alper, MP Barkley, ...
Cell Genomics 1 (2), 2021
The Data Use Ontology to streamline responsible access to human biomedical datasets
J Lawson, MN Cabili, G Kerry, T Boughtwood, A Thorogood, P Alper, ...
Cell Genomics 1 (2), 2021
The european nucleotide archive in 2020
PW Harrison, A Ahamed, R Aslam, BTF Alako, J Burgin, N Buso, ...
Nucleic acids research 49 (D1), D82-D85, 2021
OBO Foundry in 2021: operationalizing open data principles to evaluate ontologies
R Jackson, N Matentzoglu, JA Overton, R Vita, JP Balhoff, PL Buttigieg, ...
Database 2021, baab069, 2021
GA4GH: International policies and standards for data sharing across genomic research and healthcare
HL Rehm, AJH Page, L Smith, JB Adams, G Alterovitz, LJ Babb, ...
Cell genomics 1 (2), 2021

2020

SBML Level 3: an extensible format for the exchange and reuse of biological models
SM Keating, D Waltemath, M König, F Zhang, A Dräger, C Chaouiya, ...
Molecular systems biology 16 (8), e9110, 2020
FAIR principles: interpretations and implementation considerations
A Jacobsen, R de Miranda Azevedo, N Juty, D Batista, S Coles, R Cornet, ...
Data intelligence 2 (1-2), 10-29, 2020

2019

Where does an Ontology start?
H Harmse, M Courtot, W Read, N Matentzoglu, D Osumi-Sutherland, ...
ICBO, 1, 2019
BioSamples database: an updated sample metadata hub
M Courtot, L Cherubin, A Faulconbridge, D Vaughan, M Green, ...
Nucleic acids research 47 (D1), D1172-D1178, 2019
The gene ontology resource: 20 years and still GOing strong
Gene Ontology Consortium
Nucleic acids research 47 (D1), D330-D338, 2019

2018

Using OWL reasoning to support the generation of novel gene sets for enrichment analysis
DJ Osumi-Sutherland, E Ponta, M Courtot, H Parkinson, L Badi
Journal of biomedical semantics 9, 1-10, 2018
The integrated rapid infectious disease analysis (IRIDA) platform
TC Matthews, FR Bristow, EJ Griffiths, A Petkau, J Adam, D Dooley, ...
BioRxiv, 381830, 2018
Prospects for fungal bioremediation of acidic radioactive waste sites: characterization and genome sequence of Rhodotorula taiwanensis MD1149
R Tkavc, VY Matrosova, OE Grichenko, C Gostinčar, RP Volpe, ...
Frontiers in microbiology 8, 305317, 2018

2017

Dead simple OWL design patterns
D Osumi-Sutherland, M Courtot, JP Balhoff, C Mungall
Journal of biomedical semantics 8, 1-7, 2017
Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data
JA McMurry, N Juty, N Blomberg, T Burdett, T Conlin, N Conte, M Courtot, ...
PLoS biology 15 (6), e2001414, 2017
Ontobee: A linked ontology data server to support ontology term dereferencing, linkage, query and integration
E Ong, Z Xiang, B Zhao, Y Liu, Y Lin, J Zheng, C Mungall, M Courtot, ...
Nucleic acids research 45 (D1), D347-D352, 2017

2016

CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database
Baofeng Jia, Amogelang R. Raphenya, Brian Alcock, Nicholas Waglechner, Peiyao Guo, ..., Andrew C. Pawlowski, Timothy A. Johnson, Fiona S.L. Brinkman, Gerard D. Wright, Andrew G. McArthur
Nucleic Acids Research
Slim-o-matic: a Semi-Automated Way to Generate Gene Ontology Slims.
M Courtot, AL Mitchell, M Scheremetjew, JP González, LI Furlong, ...
SWAT4LS 2016, 2016
Ten Simple Rules for Biomedical Ontology Development.
M Courtot, J Malone, C Mungall
ICBO/BioCreative, 2016
From data repositories to submission portals: rethinking the role of domain-specific databases in CollecTF
S Kılıç, DM Sagitova, S Wolfish, B Bely, M Courtot, S Ciufo, T Tatusova, ...
Database 2016, baw055, 2016
The ontology for biomedical investigations
A Bandrowski, R Brinkman, M Brochhausen, MH Brush, B Bug, ...
PloS one 11 (4), e0154556, 2016
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database
B Jia, AR Raphenya, B Alcock, N Waglechner, P Guo, KK Tsang, BA Lago, ...
Nucleic acids research, gkw1004, 2016

2015

Basic Formal Ontology 2.0
M Almeida, J Bona, M Brochhausen, W Ceusters, M Courtot, R Dipert, ...
[no publisher info]
Cell, Chemical and Anatomical Views of the Gene Ontology: Mapping to a Roche Controlled Vocabulary.
D Osumi-Sutherland, E Ponta, M Courtot, HE Parkinson, L Badi
SWAT4LS, 84-93, 2015
UniProt-GOA: A central resource for data integration and GO annotation.
M Courtot, A Shypitsyna, E Speretta, A Holmes, T Sawford, T Wardell, ...
SWAT4LS 2015, 227-228, 2015
flowCL: ontology-based cell population labelling in flow cytometry
M Courtot, J Meskas, AD Diehl, R Droumeva, R Gottardo, A Jalali, ...
Bioinformatics 31 (8), 1337-1339, 2015
Basic Formal Ontology 2.0: Specification and user’s guide
B Smith, M Almeida, J Bona, M Brochhausen, W Ceusters, M Courtot, ...
National Center for Ontological Research: Buffalo, NY, USA, 50, 2015
Finding our way through phenotypes
AR Deans, SE Lewis, E Huala, SS Anzaldo, M Ashburner, JP Balhoff, ...
PLoS biology 13 (1), e1002033, 2015

2014

2013

Diagnostic criteria and clinical guidelines standardization to automate case classification.
M Courtot, J Zheng, CJ Stoeckert Jr, RR Brinkman, A Ruttenberg
ICBO, 101-104, 2013

2012

Adverse Events Following Immunization
M Courtot, RR Brinkman, A Ruttenberg
International Conference on Biomedical Ontology (ICBO) 2012, 2012
Knowledge representation in Health Research: the modeling of Adverse Events Following Immunization (EC abstract)
M Courtot
International Conference on Biomedical Ontology (ICBO) 2012 - Early Career …, 2012
Adverse events following immunization: reporting standardization, automatic case classification and signal detection (poster)
M Courtot, RR Brinkman, A Ruttenberg
International Conference on Biomedical Ontology (ICBO) 2012, 2012

2011

Controlled vocabularies and semantics in systems biology
M Pocock, DJ Wilkinson, A Lister, M Courtot, N Juty, C Knupfer, ...
Molecular Systems Biology, 2011
Reporting Adverse Events: Basis for a Common Representation.
M Courtot, RR Brinkman, A Ruttenberg
ICBO, 2011
Building the OBO Foundry ² One Policy at a Time
M Courtot, C Mungall, RR Brinkman, A Ruttenberg
[no publisher info]
Towards an Adverse Event Reporting Ontology.
M Courtot, RR Brinkman
ICBO, 2011
Overcoming the ontology enrichment bottleneck with quick term templates
P Rocca-Serra, A Ruttenberg, MJ O'Connor, PL Whetzel, D Schober, ...
Applied ontology 6 (1), 13-22, 2011
MIREOT: The minimum information to reference an external ontology term
M Courtot, F Gibson, AL Lister, J Malone, D Schober, RR Brinkman, ...
Applied Ontology 6 (1), 23-33, 2011
Controlled vocabularies and semantics in systems biology
M Courtot, N Juty, C Knüpfer, D Waltemath, A Zhukova, A Dräger, ...
Molecular systems biology 7 (1), 543, 2011

2010

Technical Note OntoFox: web-based support for ontology reuse
Z Xiang, M Courtot, RR Brinkman, A Ruttenberg, Y He
[no publisher info]
Ontology representation and ANOVA analysis of vaccine protection investigation
Y He, Z Xiang, T Todd, M Courtot, RR Brinkman, J Zheng, CJ Stoeckert Jr, ...
Bio-Ontologies 2010: Semantic Applications in Life Sciences, 18th Annual …, 2010
BioModels. net Web Services, a free and integrated toolkit for computational modelling software
C Li, M Courtot, N Le Novère, C Laibe
Briefings in bioinformatics 11 (3), 270-277, 2010
OntoFox: web-based support for ontology reuse
Z Xiang, M Courtot, RR Brinkman, A Ruttenberg, Y He
BMC research notes 3, 1-12, 2010
Modeling biomedical experimental processes with OBI
RR Brinkman, M Courtot, D Derom, JM Fostel, Y He, P Lord, J Malone, ...
Journal of biomedical semantics 1, 1-11, 2010

2009

MIREOT: the Minimum Information to Reference an External Ontology Term
A Ruttenberg, M Courtot, F Gibson, A Lister, J Malone, D Schober, ...
Nature Precedings, 1-1, 2009
Overcoming the ontology enrichment bottleneck with quick term templates
B Peters, A Ruttenberg, J Greenbaum, M Courtot, R Brinkman, P Whetzel, ...
Nature Precedings, 1-1, 2009
MIREOT: the minimum information to reference an external ontology term
M Courtot, F Gibson, A Lister, J Malone, D Schober, RR Brinkman, ...
Aug-2009, 2009
The systems biology graphical notation
NL Novère, M Hucka, H Mi, S Moodie, F Schreiber, A Sorokin, E Demir, ...
Nature biotechnology 27 (8), 735-741, 2009

2008

The OWL of Biomedical Investigations.
M Courtot, WJ Bug, F Gibson, AL Lister, J Malone, D Schober, ...
OWLED 432, 2008

2007

Adding semantics in kinetics models of biochemical pathways
N Le Novere, M Courtot, C Laibe
Proceedings of the 2nd International Symposium on experimental standard …, 2007

2006

Structural genomics on membrane proteins: comparison of more than 100 GPCRs in 3 expression systems
K Lundstrom, R Wagner, C Reinhart, A Desmyter, N Cherouati, T Magnin, ...
Journal of structural and functional genomics 7, 77-91, 2006
BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems
N Le Novere, B Bornstein, A Broicher, M Courtot, M Donizelli, H Dharuri, ...
Nucleic acids research 34 (suppl_1), D689-D691, 2006